| abstract |
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesteroleumic agents are provided which have the structure <IMAGE> wherein R is OH, or salts thereof or lower alkoxy; Rx is H or alkyl; X is -CH2-, -CH2-CH2-, -CH=CH-, -C 3BOND C-, -CH2CH2CH2- or -CH2O- (where O is linked to Z); Z is a hydrophobic anchor, such as <IMAGE> <IMAGE> <IMAGE> <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided. |