| abstract |
Radioiodinated benzovesamicol analogs which selectively localize in presynaptic cholinergic neurons of the general formula: <IMAGE> where X is selected from the group consisting of H, OH, NH2, NHCO-3-[I]-Ph, and a radioactive isotope of iodine, and Y is selected from the group of H and a radioactive isotope of iodine, Y being H is X contains iodine. Illustrative examples include: (+/-)-trans-2-hydroxy-5-iodo-3-(4-phenylpiperidino)tetralin; (+/-)-trans-3-hydroxy-5-iodo-2-(4-phenylpiperidino)tetralin; (+/-)-trans-5-amino-2-hydroxy-8-iodo-3-(4-phenylpiperidino)tetralin; and (+/-)-trans-2-hydroxy-5-(3-iodobenzamido)-3-(4-phenylpiperidino)tetralin. The novel radioiodinated benzovesamicol analogs may be used as radiopharmaceuticals to visualize cholinergic neurons with conventional imaging devices which are typically found in most nuclear medicine or radiology clinics. |