http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5075327-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 |
| filingDate | 1988-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bfd8b3555f16817bff1407c5e21368c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35c8e27246f88ede21e40ef1ba918317 |
| publicationDate | 1991-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5075327-A |
| titleOfInvention | Antipsoriatic agents |
| abstract | A compound and process of making thereof of formula <IMAGE> I wherein R1 is hydrogen; and A is alkyl; cycloalkyl; alkenyl; alkyl substituted with trifluoromethyl; phenyl; halophenyl; phenyl-C1-3 alkyl; phenyl-C1-3 alkyl substituted on the phenyl with 1 to 3 substituents selected from the group consisting of halo, C1-3 alkyl, and C1-3 alkoxy; or A is <IMAGE> wherein Z is lower alkyl; R2 is hydrogen or <IMAGE> R3 is hydrogen or methyl, and n is 1 to 5; Y is phenyl, is phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; Y' is hydrogen or methyl; and b and d are carbon-carbon bonds or c is a carbon-carbon bond; or the corresponding hydroxy acid of formula <IMAGE> II wherein A, and R1, R2, R3, Y and Y' are as described above, or a pharmaceutically acceptable salt of said acid, an alkyl ester of said acid, an acetylamino-substituted-C1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a alpha -monoglyceride of said acid, and b and d are carbon-carbon bonds or c is a carbon-carbon bond. The compound of formula I and II are useful in treating hyperproliferative skin diseases, such as psoriasis. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9911258-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0793489-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0793489-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6630492-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5200549-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-737735-B2 |
| priorityDate | 1988-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 221.