| abstract |
A combination intended to induce and stimulate hair growth and reduce hair loss comprising a first component containing at least one calcium antagonist in a physiologically acceptable medium and a second component containing, in a physiologically acceptable medium, at least one pyrimidine derivative having the formula: <IMAGE> (I) In formula (I) R1 represents the group <IMAGE> in which R3 and R4 are independent of each other and represent hydrogen, an alkyl, alkenyl, alkylaryl or cycloalkyl group, or R3 and R4 form a heterocycle with the nitrogen atom joined thereto, and represent an aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine or 4-alkylpiperazidinyl group, the heterocyclic groups further being substitutable at the carbon atoms by one to three low alkyl, hydroxy or alkoxy groups. In formula (I) R2 represents a hydrogen atom, an alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl or haloarylalkyl group. The addition salts of physiologically acceptable acids may also be employed. The first and second components may form part of the same composition or may be used separately, either simultaneously or in successive or separate stages. |