http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5057506-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79751aeaa9923745648e5ae7d9c35782 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-58 |
| filingDate | 1989-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be5108f81f62a9062059ccbf1ffe944a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60beaf40e616e13af3830e5b27f0e811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67cc8af86540d70ef44698c66039381a |
| publicationDate | 1991-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5057506-A |
| titleOfInvention | Certain phosphonic acids and derivatives useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade |
| abstract | The present invention is concerned with the phosphonic acids of formula I <IMAGE> (I) wherein one or both of the acidic hydroxy groups of the phosphonic acid moiety may be functionalized in form of pharmaceutically acceptable mono- or di- esters; wherein Y represent optionally substituted 2-carboxypyrrolidinyl, 2-carboxy-2,5-dihydropyrrolyl, 2-carboxy-1,2,3,6-tetrahydropyridinyl, 2-carboxy-1,2,5,6-tetrahydropyridinyl, 2-carboxypiperidinyl, 2-carboxyetrahydroquinolinyl or 2-carboxyperhydroquinolinyl, 2-carboxyl-2,3-dihydroindolyl or 2-carboxyperhydroindolyl as described herein, and in each of which the carboxy group may be functionalized in form of a pharmaceutical acceptable ester or amide; A represents a direct bond, lower alkenylene, lower alkylidene or lower alkylene provided that A does not represent a direct bond when Y represents 2-carboxypyrolidinyl; and pharmaceutically acceptable salts thereof; which are useful for the treatment of nervous system disorders in mammals and as antagonists of the N-methyl-D-aspartate sensitive excitatory amino acid receptor. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9640190-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5217963-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AT-408099-B |
| priorityDate | 1985-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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