| abstract |
Novel 19-nor-steroids of the formula <IMAGE> I wherein R1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R2 is a hydrocarbon of 1 to 8 carbon atoms, X is the remainder of a pentagonal or hexagonal ring optionally substituted and optionally containing one unsaturated-bond, the A and B rings are selected from the group consisting of <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) <IMAGE> (d) <IMAGE> (e) R' and R'' are individually selected from the group consisting of hydrogen, -CN and alkyl of 1 to 4 carbon atoms, Rx is selected from the group consisting of hydrogen and ORe, Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl, Ra may be in the E or Z positions as indicated by the wavy line and is selected from the group consisting of <IMAGE> and acyloxy, R'a and R''a are alkyl of 1 to 4 carbon atoms or taken together with the nitrogen atom form a heterocycle of 5 to 6 chain members optionally containing another heteroatom-with the proviso that when A and B are <IMAGE> wherein R' and R'' are both hydrogen, R1 contains at least one nitrogen, phosphorus or silicium atom and when A and B are <IMAGE> R1 is not a linear alkyl and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antiglucocorticoid activity, their preparation and novel intermediates. |