| abstract |
This invention is directed to compounds of formula (I): <IMAGE> (I) wherein R1 is thiocyano, -CH2CN, -NH2, -NHR5, or -CH2OR5 where R5 is lower alkyl; R2 is hydrogen, halo, lower alkyl, or lower alkylthio; R3 is hydrogen, halo, lower alkyl, lower alkylthio, or thiocyano; R4 is hydrogen, halo, lower alkyl, lower alkoxy, lower alkylthio, or lower alkylsulfonyl; and Y is -O-CH2-, -S-CH2-, -CH=CH-, or -(CH2)n- where n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof. These compounds are useful in treating mammals having disease-states characterized by excessive gastric acid secretion. |