| abstract |
A cinnamoylamide derivative of general formula: <CHEM> wherein, (i) when R<2> represents a methyl group and R<3> represents a hydrogen atom, (R<1>)n represents a 3-pentyl, 4-pentyl, 4-neopentyl, 4-(2-ethylbutyl), 4-(2-methylpentyl), 2-fluoro-4-pentyloxy, 4-butylthio, 4-cyclobutylmethyl, 4-cyclohexylmethyl, 4-(4-phenylbutyl) or 4-phenoxy, and (ii) when R<2> represents a hydrogen atom and R<3> represents a methyl group, (R<1>)n represents 3-pentyl or 4-phenethyl] and non-toxic salts thereof possess inhibitory activity on 5 alpha -reductase, indicative of utility for treating and/or preventing alopecia, acne or prostatic hypertrophy. a |