| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-335 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-10 |
| filingDate |
1988-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1991-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65317c617fa256c91e5fda4fc16498b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_097b8b8354853622026f795d105a89c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61f8f0a8979863ea854cfc61eeaba405 |
| publicationDate |
1991-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5036105-A |
| titleOfInvention |
5-lipoxygenase inhibitors |
| abstract |
This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein R 1 and R 2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R 3 is n a) ##STR2## wherein R 4 is hydrogen or lower alkyl; b) ##STR3## c) ##STR4## wherein R 6 and R 7 may be the same or different and are alkyl of 1 to 4 carbon atoms; or n d) ##STR5## and the pharmaceutically acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5393764-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5334616-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5162365-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3791880-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4008327-A1 |
| priorityDate |
1987-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |