| abstract |
A sustained release, reservoir-type subcutaneous implant device for the sustained administration to a subject of a biologically active compound comprises: an effective amount of a biologically active compound; an amount of a solid hydrophilic polymer sufficient to cause swelling of the device by osmotic pressure after implantation; an effective amount of a solubilizing agent; and a sufficient amount of a non-porous rate-controlling membrane which completely encapsulates said biologically active compound, wherein said rate-controlling membrane is permeable to said biologically active compound, but is impermeable to said solubilizing agent. This device is particularly advantageous for the administration of growth promoting compounds to livestock. |