http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5034521-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5128cfc84a0fb189fceb3cd240c44493 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 |
| filingDate | 1989-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e84051cb2303f92ab4901f6bda14db7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c88c90656df57774c6d6162b5b376cec |
| publicationDate | 1991-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5034521-A |
| titleOfInvention | Process for preparing 3-substituted methyl-3-cephem-4-carboxylic acid |
| abstract | A novel process is disclosed for preparing a 3-substituted methyl-3-cephem-4-carboxylic acid or pharmaceutically acceptable salt thereof. The process comprises reacting a 3-acetoxymethyl-3-cephem-4-carboxylic acid or pharmaceutically acceptable salt thereof with a specific compound, such as a boric acid ester, an orthoester or an acetal, in the presence of at least one specific catalyst selected from the group consisting of Lewis acids or complexes thereof, proton acids and mixtures thereof. In the process, formation of impurities, such as a lactone, is sufficiently suppressed without protection of the carboxylic acid, so that the high purity desired product, i.e., a 3-substituted-methyl-3-cephem-4-carboxylic acid or pharmaceutically acceptable salt thereof, which is useful as an intermediate for various cephalosporin antibiotics having excellent antimicrobial activity, can be prepared in one step in high yield. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5451675-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6620930-B1 |
| priorityDate | 1988-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 171.