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filingDate 1989-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1991-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_448d0a421eaf740af3833315d64cabac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dceadf34efb0f458422bd92ae6dc0097
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publicationDate 1991-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5030750-A
titleOfInvention Process for preparing DL-serine and process for separation and purification of the same
abstract Disclosed is a process for preparing DL-serine, which comprises synthesizing DL-serine according to Strecker reaction with use of a cyan compound, ammonium chloride, ammonia and a reaction substrate comprising glycol aldehyde, wherein the Strecker reaction is carried out under the reaction conditions of: n molar ratios of the starting materials of: n glycol aldehyde/cyan compound: more than 1.0 and not more than 1.50 n ammonium chloride/glycol aldehyde: more than 1.0 and not more than 2.0 n ammonium/cyan compound: 1.0 to 7.0 n reaction temperature: 20° to 80° C. n reaction time: 15 to 120 minutes, n and the reaction product obained in hydrolyzed. n Disclosed is also a process for separation and purification of DL-serine produced in the above by subjecting the aqueous solution containing DL-serine alkali salt obtained to ion exclusion chromatography by use of a strongly acidic cation exchange resin, neutralizing the fractionated DL-serine fractions to near the isoelectric point of DL-serine and subjecting the neutralized product to ion exclusion chromatography with a strongly acidic cation exchange resin.
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