| abstract |
The invention relates to Δ 4 -androstene derivatives with aromatase-inhibiting activity having the formula: ##STR1## wherein R 1 =O, (αR 5 ,βH) or N--O--R 6 ; n R 2 =H, (1-12C)hydrocarbon radical, --SH, --S--(1-12C)-hydrocarbon radical or (1-12C)acyl; n R 3 =O or (αR 7 ,βR 8 ); n R 4 =H or (1-12C)hydrocarbon radical; n R 5 =OH, O--(1-12C)hydrocarbon radical or O--(1-12C)acyl; n R 6 =H or (1-12C)hydrocarbon radical; n R 7 =H or (1-12C)hydrocarbon radical; and n R 8 =OH, O--(1-12C)acyl or O--(1-12C)hydrocarbon radical with the proviso that R 1 is not O if R 4 is H. |