| abstract |
Novel lipid derivatives of the formula ##STR1## [wherein R 1 is alkyl or alkylcarbamoyl; R 2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R 3 is a chemical binding or alkylene which may be substituted; R 4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R 4 , may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent. |