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filingDate 1989-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1991-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36e7fa4da2ff7c847d21fb41128e547f
publicationDate 1991-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5019658-A
titleOfInvention Separation of pure optical stereoisomers by pressure crystallization
abstract The instant invention is an improvement in the method of producing optically pure sterioisomers from a racemic mixture. The method is based on the well-known fact that a supersaturated solution or melt of the racemic mixture can be seeded with just the crystals of the desired stereoisomer, which will then crystallize out selectively, leaving the undesired stereoisomer behind in the liquid mother liquor. The desired isomer, in crystaline form, can then be separated by simple liquid/solid separation from the undesired isomer remaining behind in the mother liquor. In the conventional method, supersaturation is achieved by careful cooling of a saturated solution or melt. In the present invention, supersaturation is achieved by increasing the ambient pressure over the saturated solution or melt of the racemic mixture, and relying on the fact that the melting temperature of a substance increases with increasing pressure, provided there is an increase in molar volume when the substance melts.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012193574-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018203264-A1
priorityDate 1989-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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