http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5019590-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_058e0be30e00d53858c67167df60aed5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 1989-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75b319c1091103cb2a5fa0344366066c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16af82d2030ea7ebc180685d05378358 |
| publicationDate | 1991-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5019590-A |
| titleOfInvention | Antimalarial analogs of artemisinin |
| abstract | A process for synthesizing oxygen-containing polyoxatetracycle compounds and in particular analogs of the antimalarial agent known as qinghaosu or artemisinin is disclosed. The process employs as a reactant an olefinically unsaturated bicyclic bridging ketone having nonenolizable bridgehead moieties for both of its alpha positions. This ketone is converted to a vinylsilane that is subjected to ozonolytic cleavage of its olefinic bond to yield a member of a family of unique carboxyl/carbonyl-substituted vinylsilanes which may in turn optionally be subjected to a wide range of reactions prior to a final ozonolysis/acidification step which closes the oxygen-containing ring structure. The various intermediates are claimed as aspects of this invention as are novel tetracycles and their use as antimalarials. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5107010-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5225554-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5225427-A |
| priorityDate | 1986-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.