| abstract |
Hybridoma cell lines are made that produce monoclonal antibodies having, among others, the following identifying characteristics: (1) bind to IL-1 activated endothelial cells; (2) do not bind significantly to normal resting endothelial cells; (3) do not bind significantly to normal resting or IL-1 activated epidermal keratinocytes or resting or IL-1 activated fibroblasts. The monoclonal antibodies are used in therapeutic compositions for blocking inflammatory responses associated with activated endothelial cells. |