| abstract |
Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: <IMAGE> FORMULA A wherein: R1 is aryl, lower alkyl, cycloalkyl or hydrogen; R2 is aryl, lower alkyl or hydrogen; R3 is lower alkyl, hydroxy, or hydrogen; R4 is aryl or hydrogen; R5 is aryl or hydrogen; m is two or three; n is zero, one or two, provided that when R3 is hydroxy, n is one or two; and q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are calcium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism and also for treatment of spinal injuries. |