| abstract |
Therapeutically useful isoquinolinone derivatives of the formula A-X-R3, wherein A represents a group of the formula: <IMAGE> wherein R1 and R2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R6O- wherein R6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R3 represents a group of the formula: -Y1-CH2-CH(OH)-CH2-COOR5 wherein Y1 represents carbonyl, hydroxymethylene or -C(OR)2- wherein R represents alkyl or the two R symbols together represent alkylene and R5 represents hydrogen or optionally substituted alkyl or R3 represents a lactol or lactone ring, and pharmaceutically acceptable salts thereof, processes for their preparation and compositions containing them are described. |