| abstract |
Azole derivatives of the formulas n n R.sup.1 --CR.sup.2 R.sup.3 --CHR.sup.4 --CR.sup.5 R.sup.6 --R.sup.7 n n are described; n wherein R 1 is a heterocyclyl radicla selected from 1,2,4-triazolyl, optionally-substituted imidazolyl, pyridyl and pyrimidinyl radicals; R 2 and R 3 , which may be the same or different, are each a hydrogen atom or a 1-6C alkyl radical; R 5 and R 6 , which may be the same or different, are each a hydrogen or fluorine atom or a 1-6C alkyl radical; one of R 4 and R 7 is a 2-pyridyl or 2-thienyl radical, optionally bearing one or more substituents selected from halogen atoms, cyano radicals and 1-4C halogenoalkyl and halogenoalkoxy radicals, and the other of R 4 and R 7 is a 4-cyanophenyl radical or a 2-pyridyl or 2-thienyl radical optionally substituted as defined above. Processes for their preparation are described, as is their use as aromatase inhibitors, for example in the treatment of cancer, as plant antifungal agents or as plant growth regulatory agents. |