http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4996223-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7105207ca740add5aa1300e0c7f20a8a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 |
| filingDate | 1987-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c53c9016d7f133da58d2a1645e3a6557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28930907bf4382d64ff59d25846d361c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0e1c7f7f21d6330e82cab5ddc0118c5 |
| publicationDate | 1991-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4996223-A |
| titleOfInvention | New organic compounds having opioid properties |
| abstract | PCT No. PCT/GB87/00457 Sec. 371 Date Feb. 9, 1989 Sec. 102(e) Date Feb. 9, 1989 PCT Filed Jun. 30, 1987 PCT Pub. No. WO88/00193 PCT Pub. Date Jan. 14, 1988.New echiboline derivatives with opioid properties which are 6-hydroxy-9-methyl-echiboline derivatives having, in the 10-position, a hydrocarbon substituent of up to 4 carbon atoms-preferably a group R.CH2- (wherein R represents a hydrogen atom or a hydrocarbon group of up to 3 carbons) and especially a methyl, cyclopropyl-methyl or allyl group. These are made by dealkylating corresponding 6-alkoxy-9-methyl-10-substituted echibolines, thereby converting the 6-alkoxy group to a 6-hydroxy group, especially using boron tribromide as dealkylating reagent. Specific examples are 6-hydroxy-9,10-dimethyl-echiboline, 6-hydroxy-9-methyl-10-allyl-echiboline and 6-hydroxy-9-methyl-10-cyclopropylmethyl-echiboline. The compounds may be in free base or salt form, and be incorporated as active ingredient into pharmaceutical compositions. Also, the corresponding 6-alkoxy-9-methyl-10-substituted echiboline derivatives as useful novel intermediates, which may be made from a 6-alkoxy-9-methyl-echiboline by (A) reaction with a reagent which introduces the desired substituent into 10-position or (B) acylating to introduce the substituent R-CO- into the 10-position and reducing the acyl group to RCH2-. |
| priorityDate | 1986-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.