http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4992432-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-06 |
| filingDate | 1990-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92f9f2b4a04025f5905b206b2d734e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d8baf8e06060c989f0d3dabc7d8a120 |
| publicationDate | 1991-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4992432-A |
| titleOfInvention | 3-phenyl-thiazepinones as calcium regulating agents |
| abstract | Compounds of the formula <IMAGE> I wherein R1 is phenyl substituted with 1 to 3 substituents selected from the group consisting of halogen and lower alkoxy; R2 is hydrogen, lower alkyl, lower alkanoyl, lower cycloalkanoyl, <IMAGE> <IMAGE> R3 and R4 are independently lower alkyl, phenyl lower alkyl or together form a piperidine or pyrrolidine ring; n is 2 ro 4; m is 1 to 2; and pharmaceutically acceptable acid addition salts thereof, with the proviso that when R1 is 4-methoxyphenyl, R2 is hydrogen and R3 and R4 are methyl; and n is 2, the compound of formula I cannot be in the (-)-cis form, are described. The compounds of formula I are active as calcium channel blockers and accordingly, are useful as agents for treating ischemia. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002115655-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6541479-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6951860-B2 |
| priorityDate | 1990-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 249.