| abstract |
The invention relates to quinazoline derivatives which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. n The invention provides a quinazoline of the formula: ##STR1## wherein R 1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R 1 is substituted alkyl or alkoxy each of up to 3 carbon atoms; n R 2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl or halogenoalkyl each of up to 6 carbon atoms; n Ar is phenylene or heterocyclene; n L is a group of the formula --CO.NH-- or --CO.NR 3 --, wherein R 3 is alkyl of up to 6 carbon atoms; and n Y is hydrogen or alkyl, cycloalkyl, alkenyl or alkynyl each of up to 6 carbon atoms; or n Y is a group of the formula --A--Y 1 in which A is alkylene of up to 6 carbon atoms and Y 1 includes hydroxy, amino and cyano, and alkoxy, alkylamino and alkylthio each of up to 6 carbon atoms. |