| abstract |
2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the groups CH 2 --C.tbd.C--(CH 2 ) m R 5 and CH═CH--(CH 2 ) n R 5 (where m is 1-4, n is 0-3 and R 5 includes phenyl, COOR 9 , where R 9 is H or alkyl of 1-4 carbons, AR 6 l (where A is a methylene chain and R 6 is a variety of groups including Cl, Br, I, CHO, CN, COOR 9 , NH 2 , SC(NH)NH 2 , phenyl, P(O)(OR 9 ) 2 , etc.), and CHR 7 R 21 (where R 7 is a variety of aromatic and heterocyclic groups and R 21 is H, optionally substituted phenyl and a variety of heterocyclic groups). |