| abstract |
Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group, n in which R is hydrogen atom, an alkyl group, --(CH 2 CH 2 O)nCH 3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## group, in which R 1 and R 2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH 2 CH 2 O)nCH 3 group (n has the meaning as referred to) or R 1 may form a heterocyclic ring together with R 2 and nitrogen or oxygen atom, --CH 2 OR 3 group or ##STR3## group, in which R 3 and R 4 are same or different independently and each is hydrogen atom or an alkyl group, n X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR 5 group, in which R 5 is hydrogen atom or an acyl group. n The derivatives and salts thereof are useful for the treatment of complications of diabetes. |