| abstract |
A porous polysaccharide gel is cross-linked in that (a) the gel is substituted with a monofunctional reagent having at least one functional group that can be activated, (b) the functional group of the reagent is activated, (c) the activated group is reacted, (d) the resulting product is, optionally, reacted with the monofunctional reagent, (e) the steps (b) and (c) are repeated, and (f) the steps (d) and (e) are repeated at least once. |