| abstract |
A pyridine derivative of formula <CHEM> wherein X<1>-X<2> represents <CHEM> <CHEM> wherein wherein R<4> represents hydrogen alkyl or a substituted or unsubstituted aralkyl; R<5> reoresents a hydrogen, alkoxy or alkylthio and R<6> and R<8>, which may be the same or different, each represent hydrogen, alkyl or alkenyl, R<7> represents hydrogen or R<6> and R<7> are taken together to form <CHEM> wherein R<9> represents alkyl; and m represents an integer of from 1 to 3; and any one of a, b, and c represents a nitrogen or an N-oxide (N->O), with the other two representing a carbon atom, which exhibits selective, potential, and long-lasting inhibitory activity on biosynthesis of thromboxane A2 and is useful in the treatment and prevention of a broad range of diseases. |