| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 |
| filingDate |
1989-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1990-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87de0e41b49b326c6e7d509bdaa93fca |
| publicationDate |
1990-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4963671-A |
| titleOfInvention |
Process for resolving chiral intermediates used in making calcium channel blockers |
| abstract |
This process enables preparation of the preferred (+)-threo enantiomer by resolution of its racemic mixture of a compound of the formula ##STR1## wherein Y 1 and Y 2 are each independently lower alkyl and R 1 is hydrogen or lower alkyl. The compound is treated with a chiral acid (tartaric aicd preferred) in an organic solvent (ethanol preferred) to yield the (+)-threo enantiomer, which is then recovered from the reaction mixture. This enantiomer may then be used to produce the preferred (+)-cis enantiomer of certain benzothiazepine cardiovascular agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7704990-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7879840-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6472533-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-014941-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007024717-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8022058-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0061589-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7393652-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710045-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006194767-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7544678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5144025-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7718644-B2 |
| priorityDate |
1989-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |