http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4950681-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 1988-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5f8d16a359e23012711f196f023cce7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a04378f5d07d5a3d1daa9811705be5f |
| publicationDate | 1990-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4950681-A |
| titleOfInvention | Ketone derivatives |
| abstract | The invention relates to ketones of the general formula (I): ##STR1## wherein R 1 represents a hydrogen atom or a group selected from C 1-6 alkyl, C 3-6 alkenyl, C 3-10 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, phenylC 1-3 alkyl, --CO 2 R 8 , --COR 8 , --CONR 8 R 9 or --SO 2 R 8 (wherein R 8 and R 9 , which may be the same or different, each represents a hydrogen atom, a C 1-6 alkyl or C 3-7 cycloalkyl group, or a phenyl or phenylC 1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C 1-4 -alkyl, C 1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R 8 does not represent a hydrogen atom when R 1 represents a group --CO 2 R 8 or --SO 2 R 8 ); n R 2 represents a hydrogen atom or a C 1-6 alkyl, C 3-6 alkenyl, C 3-7 cycloalkyl, phenyl or phenylC 1-3 alkyl group; n R 3 and R 4 , which may be the same or different, each represents a hydrogen atom or a C 1-6 alkyl group; or R 2 and R 3 may together represent an alkylene chain -(CH 2 ) n --, where n represents 1, 2 or 3; n one of the groups represented by R 5 , R 6 and R 7 is a hydrogen atom or a C 1-6 alkyl, C 3-7 cycloalkyl, C 3-6 alkenyl, phenyl or phenylC 1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C 1-6 alkyl group; n Q represents a hydrogen atom or a halogen atom or a hydroxy, C 1-4 alkoxy, phenylC 1-3 alkoxy or C 1-6 alkyl group or a group --NR 10 R 11 or --CONR 10 R 11 (wherein R 10 and R 11 , which may be the same or different, each represents a hydrogen atom or a C 1-4 alkyl or C 3-4 alkenyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring); n and physiologically acceptable salts and solvates thereof. n The compounds are potent and selective antagonists of the effect of 5-HT and 5-HT 3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5310930-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5202343-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5354769-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5102901-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005176705-A1 |
| priorityDate | 1987-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.