http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4948898-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-587 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-74 |
| filingDate | 1989-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_218cd8927570f238b956c37446eb1f75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_674ae1aeea3ba0fe2313e7f4ea9548a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d6445023c877aae2933ee64e7ad5a96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_130d1fa58a6338dbfb72b00237f14dac |
| publicationDate | 1990-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4948898-A |
| titleOfInvention | Process for the manufacture of 1-sulpho-2-oxoazetidine derivatives |
| abstract | The manufacture of 1-sulpho-2-oxazetidine derivatives of the formula <IMAGE> I in which Het is an optionally amino-substituted, 5- or 6-membered, aromatic heterocycle containing 1 or 2 nitrogen atoms and optionally also an oxygen or sulphur atom, R1 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkenyl-lower alkyl, lower alkoxycarbonyl-lower alkyl, phenyl-lower-alkoxycarbonyl-lower alkyl, nitrophenyl-lower-alkoxycarbonyl-lower alkyl or carboxy-lower alkyl and R2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxycarbonyl, lower alkanoyloxy-lower alkyl, lower alkoxycarbonyl-lower alkenyl, hydroxyiminomethyl, lower alkoxyiminomethyl, carbamoyl, carbamoyl-lower alkenyl or carbamoyloxy-lower alkyl, the group =NOR1 being present at least partially in the syn-form, in racemic form or in the form of the 3S-enantiomer, and of readily hydrolyzable esters and pharmaceutically compatible salts of these compounds, by acylating a compound of the formula <IMAGE> II in which R20 equals R2 or can also represent a 2,2-dimethyl-1,3-dioxolan-4-yl group and R3 is hydrogen or sulpho, or a salt thereof with a thioester of the formula <IMAGE> III in which Het is as above and R10 has any of the values of R1 except carboxy-lower alkyl, and can also represent a tri-lower alkyl-silyl-lower-alkoxycarbonyl-lower alkyl group or a carboxy-lower alkyl group converted into a readily hydrolyzable ester group, and the group =NOR10 is present at least partially in the syn-form, and carrying out subsequent steps (N-sulphonation, conversion of R20 into R2, R10 into R1), some of which are optional. The invention also provides certain novel products of formula I and benzthiazolyl thioesters of formula III per se and the preparation of the benzthiazolyl thioesters by esterifying corresponding carboxylic acids. Finally, the invention provides a process for the preparation of carboxylic acids in which R1 is t-alkoxycarbonylmethyl. The compounds of formula I have antimicrobial activity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104387337-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5589594-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5637721-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5488918-A |
| priorityDate | 1982-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1195.