| abstract |
For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula <IMAGE> (I) in which R1 is aryl or heteroaryl, R2 is cycloalkyl or optionally substituted alkyl, R3 is hydrogen or cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl, X is -CH2-CH2- or -CH=CH-, A is <IMAGE> R6 is hydrogen or alkyl, and R7 is hydrogen, a cation or alkyl, aryl or aralkyl. |