| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_604e07c32377cab416660b10fd8f494c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 |
| filingDate |
1988-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1990-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c52eb6adbd1a88bbf76460d03354f4f |
| publicationDate |
1990-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4937238-A |
| titleOfInvention |
Prevention of mammary carcinoma |
| abstract |
To reduce the risk of breast cancer, a drug is periodically administered to young mammals before pregnancy in doses of about 1 microgram to 50 micrograms per kilogram of body weight. The drug: (1) competes with and displaces estradiol 17 beta from the mammary gland cells in an effective manner to prevent the possible formation of DNA-damaging epoxide estradiol metabolites; (2) binds to breast tissue to a greater extent than estradiol 17 beta; (3) induces terminal nonlactation differentiation of the mammary gland; (4) is nontoxic and noncarcinogenic; and (5) preferably does not cause anti-ovulatory activity. The drug is selected from a group of drugs including: (1) 4-OH estradiol; (2) d-equilenin; and (3) 17 alpha ethynyl estriol. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005070488-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-100374116-C
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010113346-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5962667-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005261209-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987240-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7923440-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236785-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004186086-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10201611-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004037269-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005215538-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-743586-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004198710-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004006936-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006247221-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9034854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9825626-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8048869-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004192620-A1 |
| priorityDate |
1986-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |