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publicationDate 1990-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4927628-A
titleOfInvention Vaccine against rotavirus diseases and method of preparing same
abstract A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.
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