| abstract |
Compounds of the following formula have pharmacutical properties: ##STR1## in which R 1 and R 2 independently are hydrogen, halo, nitro, amino, C 2-5 acylamino, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R 1 and R 2 together form a C 3-5 alkylene bridge, R 3 is C 1-4 alkyl or C 2-4 alkenyl, and X is (i) --(CH 2 ) n N(R 4 ) 2 where each R 4 independently is C 1-4 alkyl, C 2-4 alkenyl or optionally substituted C 6 H 5 CH 2 --, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C 1-3 alkylene chain; and salts thereof. |