http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4897475-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_680dd0699e3f4ba8532d128c7152b3bb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1988-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbd10c1a6adf13e4f587ecaea4547b11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb8ef0e4f01d78e5b7a8a59d84bc4fce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae71ce92b522b6549d9a66db71dbf617 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c33c1161685c284801f9d1fcc077196 |
| publicationDate | 1990-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4897475-A |
| titleOfInvention | Process for synthesis of 5α-cholest-8(14)-en-3β-ol-15-one and other 15-oxygenated sterols |
| abstract | A process for preparing 15-oxygenated sterols, such as 3 beta -hydroxy-5 alpha -cholest-8(14)-ene-15 one, comprising converting 7-dehydrocholesterol to 3 beta -benzoyloxycholesta-5,7-diene, converting the 3 beta -benzoyloxycholesta-5,7-diene to a 3 beta -benzoyloxy-5-cholesta-7,14-diene, converting the 3 beta -benzoyloxy-5-cholesta-7,14-diene to a 3 beta -benzoyloxy-14 alpha , 15 alpha -epoxy-5-cholest-7-ene and converting the 3 beta -benzoyloxy-14 alpha , 15 alpha -epoxy-5-cholest-7-ene to a 15-oxygenated sterol. Preferably, the 3 beta -benzoyloxy-cholesta-5,7-diene is converted to a 3 beta -benzoyloxy-5-cholesta-7,14-diene by (i) contacting 3 beta -benzoyloxy-cholesta-5,7-diene, in a solvent at a temperature of at most about -55 DEG C, with HCl at a concentration of at least about 2.0 M for a time sufficient to convert the 3 beta -benzoyl-oxycholesta-5,7-diene to a 3 beta -benzoyloxy-5-cholesta-7,14-diene; (ii) neutralizing the resultant reaction mixture with a base to prevent formation of a significant amount of 3 beta -benzoyloxy-5-cholesta-8,14-diene; and (iii) recovering the 3 beta -benzoyloxy-5-cholesta-7,14-diene. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5594479-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0468712-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0495649-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0771659-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5796415-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5365255-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0771659-A3 |
| priorityDate | 1988-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.