http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4885303-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 |
| filingDate | 1988-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1989-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c03c4a93dc0cd824a11a8e5d7ad6047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_543d0deda4da971d6f6702fa2c1c22d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e236a59598db5d04ea38c37d75ee980f |
| publicationDate | 1989-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4885303-A |
| titleOfInvention | Circulation-active tetrahydropyridine-3-carbonitrile derivatives |
| abstract | Circulation active tetrahydropyridines of the formula <IMAGE> in which R1 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 20 carbon atoms and can be interrupted in the chain by an oxygen atom or a sulphur atom and/or can be substituted by halogen, cyano, hydroxyl, acyloxy, nitro or nitrooxy, or by a phenyl, phenoxy, phenylthio or phenylsulphonyl group which is optionally substituted by halogen, cyano, dialkylamino with in each case 1 or 2 carbon atoms per alkyl group, alkoxy with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms, trifluoromethyl or nitro, or by an alpha -, beta - or gamma -pyridyl group, or by an amino group, this amino group carrying 2 identical or different substituents from the group comprising alkyl with up to 4 carbon atoms, alkoxyalkyl with up to 4 carbon atoms, phenyl and aralkyl, and these substitutents optionally forming, with the nitrogen atom, a 5- to 7-membered ring which can contain, as a further hetero atom, an oxygen or sulphur atom or an N-phenyl or N-alkyl grouping, this alkyl group containing 1 to 3 carbon atoms, R2 represents phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, indolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzoxadiazolyl, benzothiadiazolyl, quinolyl, isoquinolyl, quinazolyl or quinoxalyl; wherein m denotes a number from 0 to 2 and alkyl contains 1 to 4 carbon atoms with optionally 1 to 3 fluorine atoms, R3 represents a group of the formula -CN or -COOR5, wherein R5 has the same meaning as R1 and can be identical to or different from this radical, and R4 represents hydrogen, or represents phenyl or naphthyl, and their pharmaceutically acceptable acid addition salts. |
| priorityDate | 1987-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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