http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4877779-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_695eb1303d3b64112de7673e78c6daf9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 |
| filingDate | 1988-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1989-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a68b082509218bcfafa52ba6c1d1c18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31185b0b2172592feb8eeaa076b676bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b8d229662042fd9ec40a3ca1834e9c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a10973c8d9d95090400cb64e5525b8d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_266c5e9e1ce6a72f7713b0d584015647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d0a3f09c509548e2540c39cfc7198ad |
| publicationDate | 1989-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4877779-A |
| titleOfInvention | 2-aminomethylalkynylalkyl-1,3-dithiane derivatives |
| abstract | Novel compounds and their salts are disclosed having the Formulas: <IMAGE> and <IMAGE> wherein: R1 is hydrogen, phenyl, 9H-fluoren-9-yl, 10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5-yl, 5H-dibenzo[a,d]cyclohepten-5-yl, 1,2,3,4-tetrahydro-1-naphthyl, 9H-xanthen-9-yl, 9H-thioxanthen-9-yl, 2-chloro-9H-thioxanthen-9-yl, 4H-chromanyl, diphenylmethyl, phenylcycloalkylmethyl wherein the bridgehead methylene may optionally be substituted with a hydroxy group and any of the phenyl or benzo-fused rings may be substituted with one or more R5 groups wherein R5 is selected from halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy groups; and R2 and R3, which may be the same or different, are hydrogen, lower alkyl, phenylalkyl (C1-C5), wherein the phenyl ring may be substituted with one or more R5 groups or NR2R3 taken together are pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, or 1-piperazinyl (where the 4-position may optionally be substituted with hydrogen, lower alkyl, hydroxy-substituted lower alkyl, amino-substituted lower alkyl, or acetoxy-substituted lower alkyl; R4 is hydrogen, hydroxyl or trimethylsilyloxy; Ph is an unsubstituted phenyl group or a phenyl group substituted by one or more R5 groups; and n is 2-4. Pharmaceutical compositions effective as calcium channel blockers and therapeutic methods utilizing such compounds, particularly in the treatment of irritable bowel syndrome, are also disclosed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6818656-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013157540-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6664287-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2942228-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004072864-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6664270-B2 |
| priorityDate | 1988-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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