http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4861778-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4dae7331034b6b26116b7c2f7acb115 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 |
| filingDate | 1986-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1989-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d965c865840c2dc809cc4efd937fd8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de51edd8f4f88bcd8fe11cb3666fcbf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bfd165c6a4761bc156c7b503c3774ff |
| publicationDate | 1989-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4861778-A |
| titleOfInvention | 2,3-dihydrophthalazine-1,4-diones |
| abstract | A compound having the structural formula <IMAGE> wherein R1 is hydrogen, C1-C6 alkyl, C2-C6 carbalkoxyalkyl or phenyl substituted with C1-C3 alkyl or halogen; R2 is hydrogen or C1-C6 alkyl; and R3 and R4 are the same or different and are hydrogen, C1-C3 alkyl, C1-C3 alkoxy or halogen with the provisos that if R2, R3 and R4 are hydrogen, then R1 is not methyl, n-propyl or phenyl substituted with methyl in the ortho or para position; if R1, R2 and R3 are hydrogen then R4 is not hydrogen, methyl or methoxy; and if R1 and R2 are both n-propyl or n-butyl then R3 and R4 are not both hydrogen. These compounds demonstrate utility as hypolipidemic agents. The present invention is also directed to a process for controlling hyperlipidemia in mammals comprising treating mammals with a hyperlipidemia controlling effective amount of a compound having the above-identified structural formula wherein R1 is hydrogen, C1-C6 alkyl, C2-C6 carboxyalkyl, C2-C6 carbalkoxyalkyl, phenyl or phenyl substituted with C1-C3 alkyl or halogen; R2 is hydrogen or C1-C6 alkyl; and R3 and R4 are the same or different and are hydrogen, C1-C3 alkyl, C1-C3 alkoxy or halogen. Yet another aspect of the present invention is embodied in a pharmaceutical composition comprising a compound having the above structural formula wherein R1 is hydrogen, C1-C6 alkyl, C2-C6 carboxyalkyl, C2-C6 carbalkoxyalkyl, phenyl or phenyl substituted with C1-C3 alkyl or halogen; R2 is hydrogen or C1-C6 alkyl; and R3 and R4 are the same or different and are hydrogen, C1-C3 alkyl, C1-C3 alkoxy or halogen and a pharmaceutically acceptable carrier therefor. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8481580-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008108842-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010105690-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007142303-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010222584-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5298468-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5719151-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008146544-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9278098-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005288291-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010520236-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987321-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871764-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010091257-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7326690-B2 |
| priorityDate | 1986-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 251.