| abstract |
The invention relates to cycloalkyl substituted 4-aminophenyl halo derivatives of formula (I) ##STR1## wherein n is an integer of 1 to 5; n A is >C═O or --CH 2 -- and B is, independently, --O--, --NH-- or --CH 2 --; and n either R is halogen and R 1 is unsubstituted C 1 -C 4 alkyl; or R is hydrogen and R 1 is C 1 -C 4 alkyl substituted by 1 to 4 halogen atoms, n including the pharmaceutically acceptable salts thereof. The compounds of the invention show aromatase inhibiting activity and can find use, for example, in the treatment of estrogen-dependent tumors and of prostatic hyperplasia. |