| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1dfd39878009ed672c93ba0247ee666 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-886 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 |
| filingDate |
1986-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1989-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dc4efd485e554fa21ec79c160e1990a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d69647b2aba913da6a9ce2cce6e04459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c8c965e4da128be46cdb0d1c7a0747b |
| publicationDate |
1989-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4847200-A |
| titleOfInvention |
Biosynthesis of unnatural cephalosporins |
| abstract |
A process for producing unnatural penicillins and cephalosporin derivatives thereof in which peptide analogs of ACV in which the L- alpha -aminodipyl moiety is replaced by L-S-carboxymethyl cysteine or other obvious substituents, are reacted with cyclase, epimerase, ring expansion and hydroxylase enzymes isolated from a cell free extract of a prokaryotic organism such as S. clavuligerus. The product depends upon the presence or absence of co-factors such as ferrous ion, alpha -ketoglutarate, and ascorbate. In an alternative embodiment, a penicillin analog having the formula: <IMAGE> may be reduced with L-cysteine to produce an analog of isopenicillin N which may be reacted with the enzyme reagent to produce the desired penicillin or cephalosporin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5214181-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6709859-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6066468-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9108199-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6964865-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004002133-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014243241-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003180834-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9689021-B2 |
| priorityDate |
1983-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |