| abstract |
PCT No. PCT/JP86/00204 Sec. 371 Date Jul. 30, 1987 Sec. 102(e) Date Jul. 30, 1987 PCT Filed Apr. 25, 1986.The present invention provides an immunosuppressive agent containing an effective amount of one or more of the macrolide antibiotics of the formula (I): <IMAGE> (I) (wherein each of R1, R2, R3 and R4 is a methyl or ethyl group). The immunisuppressive agent has excellent immuno-suppressive activity and can be employed as an agent for suppressing rejection occurring after organ transplantation and as an agent for treating autoimmune diseases. |