| abstract |
A method is provided for inhibiting the γ to β-globin switching in subjects afflicted with β-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell anemia by periodically introducing into the bloodstream of the subject prior to natural completion of the switching process α-amino-n-butyric acid, butyric acid, isomers or salts thereof, insulin, histone deacetylase inhibitors, or mixtures thereof. |