| abstract |
Compounds of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein L is NH or O; n X is N or CR 3 wherein R 3 is hydrogen or C 1-6 alkoxy; n Y is N or CR 4 wherein R 4 is hydrogen, halogen, CF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulphonyl, C 1-6 alkylsulphinyl, C 1-7 acyl, cyano, C 1-6 alkoxycarbonyl, C 1-7 acylamino, hydroxy, nitro or amino, aminocarbonyl, or aminosulphonyl, optionally N-substituted by one or two groups selected from C 1-6 alkyl, C 3-8 cycloalkyl, and C 3-8 cycloalkyl C 1-4 alkyl or disubstituted by C 4 or C 5 polymethylene; phenyl or phenyl C 1-4 alkyl group optionally substituted in the phenyl ring by one or two of halogen, C 1-6 alkoxy or C 1-6 alkyl groups; n R 1 and R 2 are independently selected from hydrogen, or halogen; n Z is a group of formula (a), (b) or (c): ##STR2## wherein n is 2 or 3; p is 1 or 2; q is 1 to 3; r is 1 to 3; and n R 5 or R 6 is C 1-4 alkyl; having 5-HT 3 antagonist activity, a process for their preparation and their use as pharmaceuticals. |