| abstract |
This invention encompasses prostaglandins of the formula <IMAGE> wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R2, R3, and R4 are hydrogen or lower alkyl having 1 to 4 carbom atoms or R2 and R3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R3 and R4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects. |