| abstract |
A novel sulfone compound represented by the general formula (I) ##STR1## wherein R 1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C 1 -C 3 alkyl, C 1 -C 3 alkoxy and halogen; R 2 , R 3 , R 4 and R 5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R 1 and R 2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C 1 -C 3 alkyl, C 1 -C 3 alkoxy and halogen; X is oxygen or methylkene; Y is -(CH 2 ) n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R 6 is hydrogen, C 1 -C 3 alkyl, ω-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or ω-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R 7 is hydrogen or C 1 -C 3 alkyl; and R 6 and R 7 may form a ring together with N, or ##STR3## wherein R 8 is hydrogen, C 1 -C 3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect. |