| abstract |
The pharmaceutically acceptable salts corresponding to the imidazolium hydrogen carbonates of the formula <IMAGE> I wherein the symbol Q is arylene or heteroarylene, the group -NR1R2 is a basic amino group, R3 is hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, lower alkylthio, lower alkoxy or the group -(A)n-Ra, R4 is a saturated or partially unsaturated lower hydrocarbon group, a basic amino group or the group -N=CRc-Rb, -CHRcRd, -NH-CHRcRd, -NH-CO-Re or -CHRc-CO-Re, R5 is hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, aryl or a fused benzene ring, R6 is hydrogen or lower alkyl, Ra and Rb each is aryl, heteroaryl or a basic amino group, Rc is hydrogen or lower alkyl, Rd is aryl or heteroaryl, Re is hydrogen, a saturated or partially unsaturated lower hydrocarbon group optionally attached via an oxygen atom or an aryl, heteroaryl or basic amino group optionally attached via a lower alkyl group, A is vinylene or lower alkylene, n is the integer 0 or 1 and the dotted line is an additional double bond, possess valuable antibacterial, antimycotic, protozoocidal and/or anthelmintic properties. The imidazolium bicarbonates of formula I can be used to prepare such pharmaceutically acceptable, especially water-soluble, salts in a simple and inexpensive manner. |