| abstract |
There are disclosed compounds of the formula <IMAGE> wherein R1 and R2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro; R3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms; <IMAGE> A is -CH2-, -O- or -S-; m is 1-8; n is 0-7, with the proviso that m+n</=8; or a pharmacologically acceptable salt thereof, and their use as fatty acid oxidation inhibitors possessing a significantly reduced potential for impairment of normal cardiac function, and having particular utility in the treatment of glucose and fatty acid metabolism disorders, such as diabetes. |