| abstract |
1,3-alkylsubstituted-8-(3,4-,3- or 4-substituted phenyl)xanthines and pharmaceutically acceptable salts of such compounds are disclosed. The 3-substituents are hydrogen, dimethylaminomethyl, or 2,3-dihydroxypropyloxy. The 4-substituents are selected from hydroxy, cyano, --NHCON(R 5 ) 2 , --C(═NH)N(R 5 ) 2 , --NH--C(═NH)N(R 5 ) 2 , with each R 5 independently being hydrogen or an alkyl group of one to three carbons and provided that when the 3-substituent is hydrogen the 4-substituent is not hydroxy or hydrogen. n The compounds are potent adenosine receptor antagonists having relatively low lipophilicity. The compounds are intended for use as bronchodilators and cardiotonics. |