| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-801 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0613
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-075 |
| filingDate |
1987-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1988-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_325ed28a54bee72b0ec2f41089b93d9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b286a0a0f7c941fd0e588822fe5b97ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64a383624372693c949f566e372addf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a5413caefad16a0063267bf7cc51779
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcefaaae9ddfb3ff5441f4f5daa138c6 |
| publicationDate |
1988-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4780561-A |
| titleOfInvention |
Preparation process of α-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
| abstract |
Disclosed herein is a process for preparing α-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride from 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester, prepared without using L-penylalanine methyl ester which involves problems in its stability, as a raw material. Specifically, the process comprises: bringing 5-benzyl-3,6-dioxo-2-piperazine acetic acid in the presence of methanol or 5-benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester in the presence or absence of methanol into contact with hydrochloric acid; isolating the thereby deposited α-L-aspartyl-L-phenylalanine methyl ester hydrochloride; and neutralizing said hydrochloride with an alkali as required. Preparation processes of 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4897507-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5432262-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5294714-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9114378-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315328-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315327-A |
| priorityDate |
1985-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |