http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4769465-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad3d51747a2eba1e7636894263252df4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 |
| filingDate | 1986-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1988-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5ea2eea4b2eb33ef04949a9f20894d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c41ab573afd48256e0fdb5759cadc5d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_337fc692b10ce600f6178395f6741d64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94b5d1c62c28348270a4cac751cee7a0 |
| publicationDate | 1988-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4769465-A |
| titleOfInvention | Process for the preparation of 2-(N-benzyl-N-methylamino)-ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and its hydrochloride salt |
| abstract | A new, technologically easily feasible process for the preparation of 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, comprising a partrial hydrolysis of dimethyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate in an inert organic solvent at a temperature between room temperature and the reflux temperature of the reaction mixture with an aqueous solution of alkali hydroxide and the reaction of the obtained 3-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-5 -carboxylic acid either with N-(2-hydroxyethyl)-N-benzyl-methylamine in the presence or absence of an organic solvent in the presence of N,N'-dicyclohexylcarbodiimide at a temperature of between 25 DEG and 120 DEG C. or with N-(2-haloethyl)-N-benzyl-methylamine in the presence of an inert organic solvent and of a proton acceptor at a temperature of between 25 DEG and 140 DEG C., to yield the title compound, which can be, if desired, converted to its hydrochloride salt. The hydrochloride salt is known under the generic name "nicardipine hydrochloride" and is used as a valuable therapeutic in the therapy of cerebral insufficiency. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7585978-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5475111-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008125595-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009133180-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9211239-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113072483-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5051433-A |
| priorityDate | 1985-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 170.